methyl 3-(4-methylphenylsulfonamido)benzoate

methyl 3-(4-methylphenylsulfonamido)benzoate - Names and Identifiers

Name	Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate
Synonyms	MSAB GSK549 methyl 3-(4-methylphenylsulfonamido)benzoate METHYL 3-(4-METHYLBENZENESULFONAMIDO)BENZOATE Methyl 3-(4-Methylbenzenesulfonamido)benzoate Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate Benzoic acid, 3-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester
CAS	173436-66-3

methyl 3-(4-methylphenylsulfonamido)benzoate - Physico-chemical Properties

Molecular Formula	C15H15NO4S
Molar Mass	305.35
Density	1.312±0.06 g/cm3(Predicted)
Melting Point	152-154 °C
Boling Point	456.5±55.0 °C(Predicted)
Solubility	Soluble in DMSO
Appearance	powder
Color	off-white to purple
pKa	7.88±0.10(Predicted)
Storage Condition	2-8°C
Use	MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promotes its degradation, and specifically down-regulates the Wnt/β-catenin target gene. MSAB showed a potent antitumor effect against Wnt-dependent cancer cells.

methyl 3-(4-methylphenylsulfonamido)benzoate - Reference

Reference

1: Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16(1):28-36. doi: 10.1016/j.celrep.2016.05.071. Epub 2016 Jun 16. PubMed PMID: 27320923; PubMed Central PMCID: PMC4957947.

methyl 3-(4-methylphenylsulfonamido)benzoate - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.275 ml	16.375 ml	32.749 ml
5 mM	0.655 ml	3.275 ml	6.55 ml
10 mM	0.327 ml	1.637 ml	3.275 ml
5 mM	0.065 ml	0.327 ml	0.655 ml

Last Update：2024-01-02 23:10:35

methyl 3-(4-methylphenylsulfonamido)benzoate - Reference Information

biological activity	MSAB is a selective inhibitor of Wnt/β-catenin signaling, promotes its degradation, in particular down-regulation of Wnt/β-catenin target genes. MSAB has potent anti-tumor effects.
Target	Value

Last Update：2024-04-09 21:11:58