methyl 3-(4-methylphenylsulfonamido)benzoate
Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate
CAS: 173436-66-3
Molecular Formula: C15H15NO4S
methyl 3-(4-methylphenylsulfonamido)benzoate - Names and Identifiers
methyl 3-(4-methylphenylsulfonamido)benzoate - Physico-chemical Properties
| Molecular Formula | C15H15NO4S |
| Molar Mass | 305.35 |
| Density | 1.312±0.06 g/cm3(Predicted) |
| Melting Point | 152-154 °C |
| Boling Point | 456.5±55.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | powder |
| Color | off-white to purple |
| pKa | 7.88±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Use | MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promotes its degradation, and specifically down-regulates the Wnt/β-catenin target gene. MSAB showed a potent antitumor effect against Wnt-dependent cancer cells. |
methyl 3-(4-methylphenylsulfonamido)benzoate - Reference
| Reference Show more | 1: Hwang SY, Deng X, Byun S, Lee C, Lee SJ, Suh H, Zhang J, Kang Q, Zhang T, Westover KD, Mandinova A, Lee SW. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. Cell Rep. 2016 Jun 28;16(1):28-36. doi: 10.1016/j.celrep.2016.05.071. Epub 2016 Jun 16. PubMed PMID: 27320923; PubMed Central PMCID: PMC4957947. |
methyl 3-(4-methylphenylsulfonamido)benzoate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.275 ml | 16.375 ml | 32.749 ml |
| 5 mM | 0.655 ml | 3.275 ml | 6.55 ml |
| 10 mM | 0.327 ml | 1.637 ml | 3.275 ml |
| 5 mM | 0.065 ml | 0.327 ml | 0.655 ml |
Last Update：2024-01-02 23:10:35
methyl 3-(4-methylphenylsulfonamido)benzoate - Reference Information
| biological activity | MSAB is a selective inhibitor of Wnt/β-catenin signaling, promotes its degradation, in particular down-regulation of Wnt/β-catenin target genes. MSAB has potent anti-tumor effects. |
| Target | Value |
Last Update：2024-04-09 21:11:58
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Product Name: Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate Visit Supplier Webpage Request for quotationCAS: 173436-66-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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